abstract：:We examined response to bone mineral density (BMD) gains in the MOVER study following treatment with intravenous (IV) ibandronate 1 mg/month, and investigated the characteristics of a non-responder group. At 1 year, responder rates for patients with BMD increases >0 % were similar with IV ibandronate 0.5 or 1 mg/month...

journal_title：Journal of bone and mineral metabolism

authors： Nakano T,Yamamoto M,Hashimoto J,Tobinai M,Yoshida S,Nakamura T

更新日期：2016-11-01 00:00:00

abstract：:Bone mineral density (BMD) seems not to be decreased in young patients given long-term suppressive doses of levothyroxine (LT4), but information regarding the bone microstructure in these patients is lacking. The aim of this study was to determine whether supraphysiologic doses of LT4, initiated during childhood or ad...

journal_title：Journal of bone and mineral metabolism

authors： Mendonça Monteiro de Barros G,Madeira M,Vieira Neto L,de Paula Paranhos Neto F,Carvalho Mendonça LM,Corrêa Barbosa Lima I,Corbo R,Fleiuss Farias ML

更新日期：2016-07-01 00:00:00

abstract：:Patients with MRI-proved acute painful vertebral fractures in whom conservative pain management fails are frequently referred for vertebroplasty. This study investigated the effects of treating osteoporosis on the mortality rate of patients with MRI-proved acute osteoporosis-related vertebral fractures who had undergo...

journal_title：Journal of bone and mineral metabolism

authors： Chen YC,Su FM,Cheng TT,Lin WC,Lui CC

更新日期：2016-05-01 00:00:00

abstract：:Quantitative analysis of the orientational distribution of biological apatite (BAp) crystals is proposed as a new index of bone quality. This study aimed to analyze BAp c-axis orientation in ovariectomized (OVX) monkeys treated with amino-bisphosphonates minodronic acid and alendronate as reference. Sixty female monke...

journal_title：Journal of bone and mineral metabolism

authors： Tanaka M,Matsugaki A,Ishimoto T,Nakano T

更新日期：2016-03-01 00:00:00

abstract：:The aim of this study was to explore the effects of α-zearalanol (α-ZAL) on the proliferation of mouse bone-marrow-derived mesenchymal stem cells (BMSCs) and their differentiation into osteoblasts. Six- to eight-week-old BALB/C mice were used either as recipients or as bone marrow donors. BMSCs were isolated and colle...

journal_title：Journal of bone and mineral metabolism

authors： Zong S,Zeng G,Fang Y,Peng J,Zou B,Gao T,Zhao J

更新日期：2016-03-01 00:00:00

abstract：:Osteoporosis is a systemic and metabolic bone disease. New drugs with good curative effect, fewer side effects, and high safety need to be developed urgently. Recently, simvastatin has been used to treat osteoporosis more frequently; however, its clinical effect and treatment mechanism are still unknown. With the use ...

journal_title：Journal of bone and mineral metabolism

authors： Dai L,Xu M,Wu H,Xue L,Yuan D,Wang Y,Shen Z,Zhao H,Hu M

更新日期：2016-01-01 00:00:00

abstract：:After acute spinal cord injury (SCI), rapid depletion of the sublesional skeleton occurs, particularly at the distal femur and proximal tibia. Subsequently, fragility fractures of the knee may occur. We determined the efficacy of zoledronic acid to prevent sublesional bone mineral density (BMD) loss at 6 and 12 months...

journal_title：Journal of bone and mineral metabolism

authors： Bauman WA,Cirnigliaro CM,La Fountaine MF,Martinez L,Kirshblum SC,Spungen AM

更新日期：2015-07-01 00:00:00

abstract：:We aimed to assess the prevalence of diffuse idiopathic skeletal hyperostosis (DISH) and its association with lumbar spondylosis (LS) and knee osteoarthritis (KOA) using a population-based cohort study entitled Research on Osteoarthritis/osteoporosis Against Disability (ROAD). In the baseline ROAD study, which was per...

journal_title：Journal of bone and mineral metabolism

authors： Kagotani R,Yoshida M,Muraki S,Oka H,Hashizume H,Yamada H,Enyo Y,Nagata K,Ishimoto Y,Teraguchi M,Tanaka S,Nakamura K,Kawaguchi H,Akune T,Yoshimura N

更新日期：2015-03-01 00:00:00

abstract：:Interleukin-11 (IL-11) is a bone marrow stromal fibroblast-derived cytokine with a wide spectrum of activities in different biological systems. IL-11 and IL-6 are two cytokines known to rely on osteoblast-osteoclast communication for their effects on osteoclast differentiation. Bone sialoprotein (BSP) is a mineralized...

journal_title：Journal of bone and mineral metabolism

authors： Matsumura H,Nakayama Y,Takai H,Ogata Y

更新日期：2015-03-01 00:00:00

abstract：:Rodent hindlimb unloading (HU) by tail-suspension is a model to investigate disuse-induced bone loss in vivo. Previously, we have shown that osteopontin (OPN, also known as Spp1) is required for unloading-induced bone loss. However, how unloading affects OPN expression in the body is not fully understood. Here, we exa...

journal_title：Journal of bone and mineral metabolism

authors： Ezura Y,Nagata J,Nagao M,Hemmi H,Hayata T,Rittling S,Denhardt DT,Noda M

更新日期：2015-01-01 00:00:00

abstract：:Interleukin 17 (IL-17) is a cytokine implicated in the promotion of osteoclastogenesis. Its effect has been believed not to be directly exerted on osteoclast precursors, but rather indirectly carried out via an induction of receptor activator of NF-κB ligand (RANKL), the osteoclast differentiation factor, on osteoclas...

journal_title：Journal of bone and mineral metabolism

authors： Ota M,Yanagisawa M,Tachibana H,Yokota K,Araki Y,Sato K,Mimura T

更新日期：2015-01-01 00:00:00

abstract：:Osteoarthritis is an aging-related degenerative disease that severely influences the elders' life quality. However, there have been few clinical approaches available until now. Currently, more knowledge of the pathology of osteoarthritis has been illustrated. Especially, diabetes can be the only predictor of osteoarth...

journal_title：Journal of bone and mineral metabolism

authors： Jingsheng S,Yibing W,Jun X,Siqun W,Jianguo W,Feiyan C,Gangyong H,Jie C

更新日期：2015-01-01 00:00:00

abstract：:Histomorphometry is commonly applied to study bone remodeling. Histological definitions of cortical bone boundaries have not been consistent. In this study, new criteria for specific definition of the transitional zone between the cortical and cancellous bone in the femoral neck were developed. The intra- and inter-ob...

journal_title：Journal of bone and mineral metabolism

authors： Tong XY,Malo M,Tamminen IS,Isaksson H,Jurvelin JS,Kröger H

更新日期：2015-01-01 00:00:00

abstract：:The aim of our study was to investigate the occurrence of osteonecrosis of the jaw (ONJ) after implementation of dental preventive measures before starting bisphosphonates (BPs) therapy and during treatment. All consecutive patients with bone lesions eligible for BPs treatment were prospectively evaluated. Before star...

journal_title：Journal of bone and mineral metabolism

authors： Bramati A,Girelli S,Farina G,Dazzani MC,Torri V,Moretti A,Piva S,Dimaiuta M,La Verde N

更新日期：2015-01-01 00:00:00

abstract：:Stimulation of osteoblast proliferation and differentiation is important for the in vivo bone-bonding ability of biomaterials. Previous in vitro studies have used biochemical assays to analyze osteoblast-specific gene expression in cultured osteoblasts. In this study, we generated transgenic mice harboring a monomeric...

journal_title：Journal of bone and mineral metabolism

authors： Tsukanaka M,Yamamoto K,Fujibayashi S,Pattanayak DK,Matsushita T,Kokubo T,Matsuda S,Akiyama H

更新日期：2014-11-01 00:00:00

abstract：:The exact mechanism by which focal adhesion kinase (FAK) translates mechanical signals into osteogenesis differentiation in force-subjected cells has not been elucidated. The responses to different forces differ according to the origin of cells and the type of stress applied. Therefore, the recruitment of osteoclast a...

journal_title：Journal of bone and mineral metabolism

authors： Chen YJ,Shie MY,Hung CJ,Wu BC,Liu SL,Huang TH,Kao CT

更新日期：2014-11-01 00:00:00

abstract：:The aim of the study was to assess the clinical performance of the model combining areal bone mineral density (aBMD) at spine and microarchitecural texture (TBS) for the detection of the osteoporotic fracture. The Eastern European Study is a multicenter study (Serbia, Bulgaria, Romania and Ukraine) evaluating the role...

journal_title：Journal of bone and mineral metabolism

authors： Vasic J,Petranova T,Povoroznyuk V,Barbu CG,Karadzic M,Gojkovic F,Elez J,Winzenrieth R,Hans D,CulaficVojinovic V,Poiana C,Dzerovych N,Rashkov R,Dimic A

更新日期：2014-09-01 00:00:00

abstract：:Vertebral fracture (VFx) is associated with various co-morbidities and increased mortality. In this paper, we have studied the detective value of height loss for VFx using two indices; historical height loss (HHL) which is the difference between the maximal height, and the current height (CH), and CH/knee height (KH) ...

journal_title：Journal of bone and mineral metabolism

authors： Yoh K,Kuwabara A,Tanaka K

更新日期：2014-09-01 00:00:00

abstract：:Previously, we reported that millimeter wave promoted the chondrocyte proliferation by pushing cell cycle progression. Activation of K(+) channels plays an essential role in the stimulating of extracellular matrix (ECM) synthesis and the cell proliferation in chondrocytes. While it is unclear if millimeter wave enhanc...

journal_title：Journal of bone and mineral metabolism

authors： Li X,Liu C,Liang W,Ye H,Chen W,Lin R,Li Z,Liu X,Wu M

更新日期：2014-07-01 00:00:00

abstract：:The aim of this study was to evaluate the prevalence of spine–femur discordance, and to compare the effectiveness of femoral neck (FN) and lumbar spine (LS) bone mineral density (BMD) for estimation of the risk of vertebral fractures. Women who were evaluated with dual energy X-ray absorptiometry between January 2001 ...

journal_title：Journal of bone and mineral metabolism

authors： Seok H,Kim KJ,Kim KM,Rhee Y,Cha BS,Lim SK

更新日期：2014-07-01 00:00:00

abstract：:Bone mass differs according to ethnic classification, with individuals of African ancestry attaining the highest measurements across numerous skeletal sites. Elevated bone mass is even maintained in those individuals exposed to adverse environmental factors, suggesting a prominent genetic effect that may have clinical...

journal_title：Journal of bone and mineral metabolism

authors： May A,Pettifor JM,Norris SA,Ramsay M,Lombard Z

更新日期：2013-11-01 00:00:00

abstract：:Bone health was assessed for inhabitants of an area affected by the Fukushima nuclear plant incident. Osteoporotic patients, who had been treated with active vitamin D3 and/or bisphosphonate at Soma Central Hospital before the Fukushima incident, were enrolled. Changes in bone turnover markers and bone mineral density...

journal_title：Journal of bone and mineral metabolism

authors： Ishii T,Ito K,Kato S,Tsubokura M,Ochi S,Iwamoto Y,Saito Y

更新日期：2013-11-01 00:00:00

abstract：:The objective of this study was to record the clinical course of osteoporosis over time in Japanese women. We hypothesized that successful control of acute pain associated with osteoporosis will allow better treatment for health-related problems. To confirm this working hypothesis, we developed the Japan Questionnaire...

journal_title：Journal of bone and mineral metabolism

authors： Doi T,Akai M,Endo N,Fujino K,Iwaya T

更新日期：2013-11-01 00:00:00

abstract：:Low persistence with osteoporosis medication is associated with higher fracture risk. Previous studies estimated that 1-year persistence with osteoporosis medication is low. Our aim was to study persistence with osteoporosis medication among patients with long-term follow-up (to 5 years). The InterAction Database (IAD...

journal_title：Journal of bone and mineral metabolism

authors： van Boven JF,de Boer PT,Postma MJ,Vegter S

更新日期：2013-09-01 00:00:00

abstract：:The aim was to evaluate the risk of new vertebral fractures with the increasing number and severity of prevalent vertebral fractures in women who received placebo or minodronate in a post hoc analysis of a 2-year randomized, double-blind, placebo-controlled study. The subjects were women aged 55-80 years old with 1-5 ...

journal_title：Journal of bone and mineral metabolism

authors： Hagino H,Shiraki M,Fukunaga M,Nakano T,Takaoka K,Ohashi Y,Nakamura T,Matsumoto T

更新日期：2013-09-01 00:00:00

abstract：:In order to investigate the effect of manganese (Mn) deficiency on bone metabolism in chicks, ninety 1-day-old male Arbor Acre chicks were randomly divided into 3 groups and each group were given a diet having a different concentration of Mn (60 mg kg(-1), control group; 40 mg kg(-1), Mn-deficient group I; 8.7 mg kg(-...

journal_title：Journal of bone and mineral metabolism

authors： Zhaojun W,Lin W,Zhenyong W,Jian W,Ran L

更新日期：2013-05-01 00:00:00

abstract：:In 1995, the Japanese Society for Bone and Mineral Metabolism (now the Japanese Society for Bone and Mineral Research) established the Osteoporosis Diagnostic Criteria Review Committee. Following discussion held at the 13th scientific meeting of the Society in 1996, the Committee, with the consensus of its members, pr...

journal_title：Journal of bone and mineral metabolism

authors： Soen S,Fukunaga M,Sugimoto T,Sone T,Fujiwara S,Endo N,Gorai I,Shiraki M,Hagino H,Hosoi T,Ohta H,Yoneda T,Tomomitsu T,Japanese Society for Bone and Mineral Research and Japan Osteoporosis Society Joint Review Committee for the R

更新日期：2013-05-01 00:00:00

abstract：:The dietary reference intake (DRI) of vitamin D for Korean children was reduced from 400 IU/day in 2005 to 200 IU/day in 2010. We evaluated the risk factors for low 25-hydroxyvitamin D [25(OH)D] status and its relationships with bone health in peripubertal nonobese children living in Seoul or Gyeonggi-do. One hundred ...

journal_title：Journal of bone and mineral metabolism

authors： Lee YA,Kim JY,Kang MJ,Chung SJ,Shin CH,Yang SW

更新日期：2013-05-01 00:00:00

abstract：:Disturbed zinc (Zn) homeostasis in mammals is mainly characterized by impaired bone generation accompanied with growth retardation. However, the underlying mechanisms that determine how Zn controls bone homeostasis remain to be defined. Zn homeostasis is tightly controlled by Zn transporter families. Recent studies ha...

journal_title：Journal of bone and mineral metabolism

authors： Fukada T,Hojyo S,Furuichi T

更新日期：2013-03-01 00:00:00

abstract：:Eldecalcitol reduces the risk of vertebral fractures in comparison to alfacalcidol in osteoporotic patients under vitamin D repletion. The aim of this study was to evaluate the effects of eldecalcitol on the spinal location of incident vertebral fractures, the severity of the fractures, and the changes in health-relat...

journal_title：Journal of bone and mineral metabolism

authors： Hagino H,Takano T,Fukunaga M,Shiraki M,Nakamura T,Matsumoto T

更新日期：2013-03-01 00:00:00

abstract：:Bone mineral density (BMD) and peak bone mass (PBM) are important determinants of skeletal resistance. The development of bone densitometry improved the possibility of studying BMD and the influence of genetic and environmental factors on bone. Heredity factors are important for BMD, and Runx-2 is accepted as a regula...

journal_title：Journal of bone and mineral metabolism

authors： Zanatta M,Valenti MT,Donatelli L,Zucal C,Dalle Carbonare L

更新日期：2012-11-01 00:00:00

abstract：:Hypophosphatasia is a rare inherited disorder characterized by a low serum alkaline phosphatase (ALP) activity and defective bone mineralization. Adult hypophosphatasia typically manifests in middle-age as a result of osteomalacia with recurrent stress fractures of the lower limb. However, considerable variation occur...

journal_title：Journal of bone and mineral metabolism

authors： Iida K,Fukushi J,Fujiwara T,Oda Y,Iwamoto Y

更新日期：2012-11-01 00:00:00

abstract：:The purpose of this study was to investigate the association of the Singh index, cortical thickness index (CTI) and calcar-to-canal (CC) ratio with bone mineral density (BMD) as well as their relationship with physical parameters [age, gender, height, and body mass index (BMI)] in order to assess their potential as an...

journal_title：Journal of bone and mineral metabolism

authors： Im GI,Park PG,Moon SW

更新日期：2012-09-01 00:00:00

abstract：:Menin, a product of the MEN1 gene, is related to the ontogeny of several cancers such as MEN1 and sporadic endocrine tumors, although it is considered to be a tumor suppressor. Many proteins interact with menin, and it is involved in various biological functions in several tissues. Menin plays some physiological and p...

journal_title：Journal of bone and mineral metabolism

authors： Kaji H

更新日期：2012-07-01 00:00:00

abstract：:Hyperhomocysteinemia has been shown to increase the incidence of osteoporosis and osteoporotic fractures. Endoplasmic reticulum (ER) stress was recently shown to be associated with apoptosis in several types of cells. In this study, we determined the effect of homocysteine (Hcy) on the apoptosis of osteoblastic cells ...

journal_title：Journal of bone and mineral metabolism

authors： Park SJ,Kim KJ,Kim WU,Oh IH,Cho CS

更新日期：2012-07-01 00:00:00

abstract：:We aimed to clarify changes in biochemical markers of bone turnover (BTMs) over 10 years, associations with changes in bone mineral density (BMD), and birth-cohort effects in a Japanese community. We randomly selected 400 individuals (age, 40-79 years; 50 of each gender and age stratum) from a list of registered resid...

journal_title：Journal of bone and mineral metabolism

authors： Yoshimura N,Muraki S,Oka H,Kawaguchi H,Nakamura K,Akune T

更新日期：2011-11-01 00:00:00

abstract：:Serum 25-hydroxyvitamin D (25-OHD) concentrations are thought to accurately reflect vitamin D stores, and vitamin D deficiency causes secondary hyperparathyroidism, irreversible bone loss, and increased risk of fracture. Recent studies suggest that decrease of serum 25-OHD level in mothers could increase the risk of p...

journal_title：Journal of bone and mineral metabolism

authors： Shibata M,Suzuki A,Sekiya T,Sekiguchi S,Asano S,Udagawa Y,Itoh M

更新日期：2011-09-01 00:00:00

abstract：:We previously reported that simvastatin induces estrogen receptor-alpha (ERα) in murine bone marrow stromal cells in vitro. In this study, we investigated the effect of simvastatin on ERα expression in bone and uterus in ovariectomized (OVX) rats and evaluated bone mass, bone strength, and uterine wet weight. Three-mo...

journal_title：Journal of bone and mineral metabolism

authors： Li X,Song QS,Wang JY,Leng HJ,Chen ZQ,Liu ZJ,Dang GT,Song CL

更新日期：2011-07-01 00:00:00

abstract：:Chronic liver disease in adults is a risk factor of osteoporosis, but little is known about risk of fractures in children with non-cholestatic liver disease. The aim of this study was to investigate associations among the severity of liver fibrosis, bone mass and low-energy fractures in children. History of fractures,...

journal_title：Journal of bone and mineral metabolism

authors： Konstantynowicz J,Lebensztejn DM,Skiba E,Sobaniec-Lotowska ME,Abramowicz P,Piotrowska-Jastrzebska J,Kaczmarski M

更新日期：2011-05-01 00:00:00

abstract：:Parathyroid hormone (PTH) is a potent anabolic agent, but the cellular mechanisms by which it increases bone mass are not fully understood. Dickkopf 1 (Dkk1) is an endogenous inhibitor of Wnt signaling and suppresses bone formation in vivo. We sought to determine if Dkk1 and anabolic PTH treatment interact in regulati...

journal_title：Journal of bone and mineral metabolism

authors： Yao GQ,Wu JJ,Troiano N,Insogna K

更新日期：2011-03-01 00:00:00